A. Guzaev et al., SYNTHESIS OF OLIGONUCLEOTIDE ANALOGS BY USING PHOSPHORAMIDITE REAGENTS DERIVED FROM 2,2-BIS(HYDROXYMETHYL)MALONATES, Collection of Czechoslovak Chemical Communications, 61, 1996, pp. 226-229
A new family of non-nucleosidic phospharamidite rt agents derived from
either esters or amides of 2,2-bis(hydroxymethyl)malonic acid is desc
ribed. Tile utility of the building blocks 1-5 ii demonstrated by prep
aration of 5'-phosphorylated oligonucleotides as well as hydrophobic,
polyamino and fluorescent labelled oligonucleotide analogues.