SYNTHESIS OF OLIGONUCLEOTIDE ANALOGS BY USING PHOSPHORAMIDITE REAGENTS DERIVED FROM 2,2-BIS(HYDROXYMETHYL)MALONATES

Authors
GUZAEV A SALO H AZHAYEV A LONNBERG H
Citation
A. Guzaev et al., SYNTHESIS OF OLIGONUCLEOTIDE ANALOGS BY USING PHOSPHORAMIDITE REAGENTS DERIVED FROM 2,2-BIS(HYDROXYMETHYL)MALONATES, Collection of Czechoslovak Chemical Communications, 61, 1996, pp. 226-229
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
61
Year of publication
1996
Pages
226 - 229
Database
ISI
SICI code
0010-0765(1996)61:<226:SOOABU>2.0.ZU;2-U
Abstract
A new family of non-nucleosidic phospharamidite rt agents derived from either esters or amides of 2,2-bis(hydroxymethyl)malonic acid is desc ribed. Tile utility of the building blocks 1-5 ii demonstrated by prep aration of 5'-phosphorylated oligonucleotides as well as hydrophobic, polyamino and fluorescent labelled oligonucleotide analogues.