NONENZYMATIC HYDROLYSIS OF OLIGORIBONUCLEOTIDES .3. STEREOCHEMISTRY AND INFLUENCES OF CHIMERIC DNA RNA ON NONENZYMATIC HYDROLYSIS OF OLIGORIBONUCLEOTIDES/

Authors
KIERZEK R
Citation
R. Kierzek, NONENZYMATIC HYDROLYSIS OF OLIGORIBONUCLEOTIDES .3. STEREOCHEMISTRY AND INFLUENCES OF CHIMERIC DNA RNA ON NONENZYMATIC HYDROLYSIS OF OLIGORIBONUCLEOTIDES/, Collection of Czechoslovak Chemical Communications, 61, 1996, pp. 253-257
Citations number
12
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
61
Year of publication
1996
Pages
253 - 257
Database
ISI
SICI code
0010-0765(1996)61:<253:NHOO.S>2.0.ZU;2-Q
Abstract
It has been proven that when using Rp and Sp isomers of UCGUpAA, nonen zymatic hydrolysis of phosphorothioate diester bond in the presence of PVP proceeds with the inversion of configuration at the phosphorus ce nter (I ia an in line mechanism). The application of chimeric DNA/RNA oligomers indicates the importance of some fragments of the oligomer f or the hydrolysis of phosphodiester bond.