SYNTHESIS OF URIDINE ANALOGS TO PROBE THE FUNCTIONAL-GROUP REQUIREMENTS OF THE HAIRPIN RIBOZYME

Authors
VYLE JS YOUNG KJ JONES S GRASBY JA
Citation
Js. Vyle et al., SYNTHESIS OF URIDINE ANALOGS TO PROBE THE FUNCTIONAL-GROUP REQUIREMENTS OF THE HAIRPIN RIBOZYME, Collection of Czechoslovak Chemical Communications, 61, 1996, pp. 280-282
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
61
Year of publication
1996
Pages
280 - 282
Database
ISI
SICI code
0010-0765(1996)61:<280:SOUATP>2.0.ZU;2-9
Abstract
O-4-Methyluridine, O-2-methyluridine and (4H)uridine phosphoramidites were prepared with 2'-O-silyl protection, The methyl modified pyrimidi nes were synthesised from uridine via the triazolide (O-4-methyl) or 2 ,5'-cyclo derivative (O-2-methyl). An improved synthesis of protected 4-thiouridine was also performed.