SYNTHESIS AND PROPERTIES OF 2'-O-METHOXYMETHYL OLIGONUCLEOTIDES

Authors
BIZDENA E ROZNERS E STROMBERG R
Citation
E. Bizdena et al., SYNTHESIS AND PROPERTIES OF 2'-O-METHOXYMETHYL OLIGONUCLEOTIDES, Collection of Czechoslovak Chemical Communications, 61, 1996, pp. 283-286
Citations number
10
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
61
Year of publication
1996
Pages
283 - 286
Database
ISI
SICI code
0010-0765(1996)61:<283:SAPO2O>2.0.ZU;2-4
Abstract
2'-O-Methoxymethyluridine was synthesized under mild conditions using N-iodosuccinimide (NIS) activation of a 2'-methoxythiomethyl function in presence of methanol. Oligoribonucleotides containing such modified uridine residues had slightly decreased duplex stability when compare d with full RNA duplexes. No substantial increase in stability towards snake venom phosphodiesterase (SVPD) was observed.