ADJUVANCY AND REACTOGENICITY OF N-ACETYLGLUCOSAMINYL N-ACETYLMURAMYL DIPEPTIDE (GMDP) ORALLY-ADMINISTERED JUST PRIOR TO TRIVALENT INFLUENZASUBUNIT VACCINE - A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY IN NURSING-HOME RESIDENTS

One hundred and fifty-three nursing home residents received 0, 5, 25 o r 50 mg N-acetylglucosaminyl-N-acetylmuramyl-dipeptide (GMDP) orally, and trivalent influenza subunit vaccine intramuscularly, One day after intervention, there was a strong increase of total leucocytes, monocy tes and neutrophils in the groups receiving 25 or 50 mg GMDP. A GMDP d ose dependent increase in systemic, but not in local, vaccine side-eff ects was observed. No significant differences in post-vaccination haem agglutination inhibiting serum antibody titres were observed between t he four groups, indicating that oral administration of GMDP together w ith influenza vaccination, does not lead to a higher vaccine efficacy. Copyright (C) 1996 Elsevier Science Ltd.