REVERSIBLE BONE-MARROW DEPRESSION BY HIGH-DOSE PIPERACILLIN TAZOBACTAM/

Bone marrow toxicity, mainly neutropenia, has been described as an unc ommon secondary effect of most beta-lactams, and it is usually related to large cumulative doses. Although previously described for piperaci llin, no cases of marrow depression caused by piperacillin/tazobactam have been reported to date. We report a case of reversible pancytopeni a, with evidence of bone marrow depression, which occurred after a 17d course of piperacillin/tazobactam. The drug was given to an underweig ht 18-year-old woman, at the usual dosage of 4/0.5 g three times a day . We stress the need for reducing the recommended dosage when treating underweight adult patients, and also of monitoring haematological par ameters during prolonged treatments.