LOW RESPONSE TO HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN IN THE TREATMENTOF ACQUIRED FACTOR-VIII INHIBITOR

Citation
L. Crenier et al., LOW RESPONSE TO HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN IN THE TREATMENTOF ACQUIRED FACTOR-VIII INHIBITOR, British Journal of Haematology, 95(4), 1996, pp. 750-753
Citations number
15
Categorie Soggetti
Hematology
ISSN journal
00071048
Volume
95
Issue
4
Year of publication
1996
Pages
750 - 753
Database
ISI
SICI code
0007-1048(1996)95:4<750:LRTHII>2.0.ZU;2-O
Abstract
Prednisone is the classic first-line therapy to suppress an acquired f actor VIII inhibitor and may achieve complete remission in about 30% o f patients. More recently, promising results have been reported with h igh-dose intravenous immunoglobulin (IVIg). However, after an extensiv e review of the literature, we found only three complete remissions (1 2%) among the 26 assessable patients treated by IVIg. These data are i n agreement with the low response to IVIg that we experienced in our s eries of patients. This study suggests that steroids should still be p referred to IVIg, an expansive therapy, to suppress an acquired factor VIII inhibitor.