CHOLESTEROL-CONTAINING NONIONIC AMPHIPHILIC POLYMERS - SYNTHESIS AND SOLUBILIZATION OF CHOLESTEROL

Authors
CHO I JEONG SW
Citation
I. Cho et Sw. Jeong, CHOLESTEROL-CONTAINING NONIONIC AMPHIPHILIC POLYMERS - SYNTHESIS AND SOLUBILIZATION OF CHOLESTEROL, Macromolecular chemistry and physics, 196(3), 1995, pp. 869-875
Citations number
23
Categorie Soggetti
Polymer Sciences
Journal title
Macromolecular chemistry and physics → ACNP
ISSN journal
10221352
Volume
196
Issue
3
Year of publication
1995
Pages
869 - 875
Database
ISI
SICI code
1022-1352(1995)196:3<869:CNAP-S>2.0.ZU;2-3
Abstract
Solubilization of cholesterol in water with cholesterol-containing pol y(N-vinyl-2-pyrrolidone) was studied. The non-ionic amphiphilic polyme rs were synthesized via copolymerization of cholesterol-based monomers with N-vinyl-2-pyrrolidone; the copolymers were dissolved isotropical ly in water to form hydrophobic microdomains solubilizing cholesterol efficiently. Electron micrographs revealed that the amphiphilic polyme rs undergo aggregational changes from random microphases to bilayers a s free cholesterol is incorporated into the polymeric hydrophobic doma ins.