Sj. Schermer et al., EFFECT OF FETAL THYROIDECTOMY ON BROWN ADIPOSE-TISSUE AND THERMOREGULATION IN NEWBORN LAMBS, Reproduction, fertility and development, 8(6), 1996, pp. 995-1002
The effect of fetal thyroidectomy on thermoregulation in newborn lambs
was investigated. Seven of 14 lambs born normally at term were thyroi
dectomized at Day 127 of gestation, Colonic temperature and oxygen con
sumption were measured during non-rapid eye movement sleep 6-45 h afte
r birth. All lambs were then killed and perirenal brown adipose tissue
was sampled for measurement of thermogenic activity (guanosine diphos
phate binding), uncoupling protein and lipid contents. Thyroidectomize
d lambs tended to have a mean colonic temperature 2.35 degrees C lower
(P = 0.067) than controls and two became hypothermic (i.e. colonic te
mperature <35 degrees C). Thyroidectomized lambs exhibited lower rates
of oxygen consumption (P = 0.05) and an increased incidence of shiver
ing thermogenesis. The perirenal adipose tissue of these lambs had a l
ower thermogenic activity (P < 0.01), less uncoupling protein (P < 0.0
1) and higher lipid content (P = 0.072) compared with intact controls.
It is concluded that fetal thyroidectomy results in a decreased abili
ty of newborn lambs to utilize nonshivering thermogenesis in brown adi
pose tissue as well as increasing the incidence of hypothermia, These
changes are associated with decreased synthesis of uncoupling protein
and functional development of brown adipose tissue in the late gestati
on fetus.