DEVELOPMENT OF AN ANTIVENOM AGAINST TOXINS OF LONOMIA-OBLIQUA CATERPILLARS

Authors
DASILVA WD CAMPOS ACMR GONCALVES LRC SOUSAESILVA MCC HIGAHSI HG YAMAGUSHI IK KELEN EMA
Citation
Wd. Dasilva et al., DEVELOPMENT OF AN ANTIVENOM AGAINST TOXINS OF LONOMIA-OBLIQUA CATERPILLARS, Toxicon, 34(9), 1996, pp. 1045-1049
Citations number
10
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
34
Issue
9
Year of publication
1996
Pages
1045 - 1049
Database
ISI
SICI code
0041-0101(1996)34:9<1045:DOAAAT>2.0.ZU;2-B
Abstract
Skin contact with caterpillars of Lonomia moths causes haemostatic dis orders that may evolve into a haemorrhagic syndrome. Replacement thera py has been shown to exacerbate the clinical symptoms of this envenomi ng. In this study it is shown that horses immunized with a bristle ext ract of L. obliqua caterpillars produced IgG antibodies that completel y neutralized, in vitro, the toxin(s) responsible for the blood incoag ulability observed in rats. This antivenom offers the possibility of s pecific treatment for envenoming caused by contact with caterpillars o f Lonomia moths. Copyright (C) 1996 Elsevier Science Ltd