This paper presents a knowledge-based approach for labeling two-dimens
ional (2-D) magnetic resonance (MR) brain images using the Boolean neu
ral network (BNN), which has binary inputs and outputs, integer weight
s, fast learning and classification, and guaranteed convergence. The a
pproach consists of two components: a BNN clustering algorithm and a c
onstraint satisfying Boolean neural network (CSBNN) labeling procedure
, The BNN clustering algorithm is developed to initially segment an im
age into a number of regions. Then the segmented regions are labeled w
ith the CSBNN, which is a modified version of BNN [13]. The CSBNN uses
a knowledge base that contains information on image-feature space and
tissue models as constraints, The method is tested using sets of MR b
rain images. The regions of the different brain tissues are satisfacto
rily segmented and labeled. A comparison with the Hopfield neural netw
ork and the traditional simulated annealing method for image labeling
is provided. The comparison results show that the CSBNN approach offer
s a fast, feasible, and reliable alternative to the existing technique
s for medical image labeling.