MECHANISM OF ACTION OF ASPARTIC PROTEASES .2. CONFORMATIONAL POSSIBILITIES OF A SUBSTRATE OF THE HIV-1 PROTEASE

Authors
POPOV ME KASHPAROV IV POPOV EM
Citation
Me. Popov et al., MECHANISM OF ACTION OF ASPARTIC PROTEASES .2. CONFORMATIONAL POSSIBILITIES OF A SUBSTRATE OF THE HIV-1 PROTEASE, Bioorganiceskaa himia, 22(7), 1996, pp. 510-522
Citations number
46
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
22
Issue
7
Year of publication
1996
Pages
510 - 522
Database
ISI
SICI code
0132-3423(1996)22:7<510:MOAOAP>2.0.ZU;2-P
Abstract
Theoretical conformational analysis of a hexapeptide fragment p17-p24 of the native substrate of the HIV-1 protease was reported. The geomet rical and energy parameters of all possible optimal conformations were determined. The data which are necessary for the calculation of the m echanism of the catalytic act of HIV-1 protease were obtained.