NEW AMINOOXY ANALOGS OF BIOGENIC POLYAMIN ES

A series of structural analogs of putrescine, spermidine, and spermine with the aminomethylene fragment substituted by the aminooxy group wa s suggested. The synthesis of the new aminooxy analogs of spermine was described. Biochemical aspects of the activity of the aminooxy analog s of polyamines were discussed in respect of their selective inhibitio n of normal and leukemic cells.