RADIATION-DOSIMETRY FOR I-131 MIBG THERAPY OF NEUROBLASTOMA

This paper describes the methodology which can be used to determine wh ole-body, red marrow, blood, bladder, liver, and tumour doses delivere d during I-131-mIBG therapy of neuroblastoma. The methodology is based on the Physics Protocol used in a multi-centre study undertaken by th e United Kingdom Children's Cancer Study Group (UKCCSG). In this study , the estimates of the doses delivered, using 2.4-12.1 GBq I-131-mIBG, were in the following ranges: whole body, 0.14-0.65 mGy MBq(-1); red marrow, 0.17-0.63 mGy MBq(-1); blood, 0.04-0.17 mGy MBq(-1); bladder, 2.2-5.3 mGy MBq(-1); liver, 0.3-1.9 mGy MBq(-1); and tumour, 0.2-16.6 mGy MBq(-1).