EMPYEMA FOLLOWING THE PERCUTANEOUS INSTILLATION OF ANTIFUNGAL AGENTS IN PATIENTS WITH ASPERGILLOSIS

We report two cases of empyema as a complication of the percutaneous i nstillation of antifungal drugs for pulmonary and pleural aspergillosi s. Case 1 underwent percutaneous administration of amphotericin B and fluconazole for 2 months. Six months later, the patient was found to h ave an Aspergillus empyema with a bronchopleural fistula, Case 2 with pulmonary and pleural aspergillosis underwent percutaneous administrat ion of amphotericin B for one month, Four months later, the patient un derwent pleural drainage due to empyema. Pleural biopsy revealed pleur al aspergillosis, In both cases, it was suggested that the preceding A spergillus infection and percutaneous instillation of antifungals resu lted in the development of empyema.