DEVELOPMENT OF SECONDARY LEUKEMIA ASSOCIATED WITH (1-7)(Q10-P10) IN APATIENT WITH CROW-FUKASE SYNDROME

Authors
SATOH K MIURA I CHUBACHI A UTSUMI S IMAI H MIURA AB
Citation
K. Satoh et al., DEVELOPMENT OF SECONDARY LEUKEMIA ASSOCIATED WITH (1-7)(Q10-P10) IN APATIENT WITH CROW-FUKASE SYNDROME, Internal medicine, 35(8), 1996, pp. 660-662
Citations number
10
Categorie Soggetti
Medicine, General & Internal
Journal title
Internal medicine → ACNP
ISSN journal
09182918
Volume
35
Issue
8
Year of publication
1996
Pages
660 - 662
Database
ISI
SICI code
0918-2918(1996)35:8<660:DOSLAW>2.0.ZU;2-B
Abstract
A 42-year-old woman with Crow-Fukase syndrome developed acute myeloid leukemia (M6: FAB classification) following treatment with alkylating agents (a total of 2,500 mg of melphalan and 9,800 mg of cyclophospham ide), Chromosome analysis of the bone marrow showed 49,XX,der(1;7)(q10 ;p10), +8, +19, +21 in therapy-related myelodysplastic syndrome with a dditional chromosomes 8, and 12 and two additional chromosomes 21 in a cute leukemia, Because of the risk of therapy-related leukemia, alkyla ting agents should be used with caution in the treatment of Crow-Fukas e syndrome.