DISTINCT CELLULAR COMPARTMENT OF CYCLIN-DEPENDENT KINASE-5 (CDK5) ANDNEURON-SPECIFIC CDK5 ACTIVATOR PROTEIN (P35(NCK5A)) IN THE DEVELOPINGRAT CEREBELLUM

Authors
MATSUSHITA M TOMIZAWA K LU YF MORIWAKI A TOKUDA M ITANO T WANG JH HATASE O MATSUI H
Citation
M. Matsushita et al., DISTINCT CELLULAR COMPARTMENT OF CYCLIN-DEPENDENT KINASE-5 (CDK5) ANDNEURON-SPECIFIC CDK5 ACTIVATOR PROTEIN (P35(NCK5A)) IN THE DEVELOPINGRAT CEREBELLUM, Brain research, 734(1-2), 1996, pp. 319-322
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
734
Issue
1-2
Year of publication
1996
Pages
319 - 322
Database
ISI
SICI code
0006-8993(1996)734:1-2<319:DCCOCK>2.0.ZU;2-J
Abstract
We have elucidated the spatial and temporal localization of Cdk5 and p 35(nck5a) in the developing rat postnatal cerebellum. Both proteins we re highly expressed in cell bodies of post mitotic and immature neuron s. The localization of Cdk5 in cellular compartment was changed from c ell body to the axon in development. On the other hand, p35(nck5a) was always expressed in the cell body throughout cerebellum development. The Cdk5 kinase activity was correlated with the expression of p35(nck 5a) father than that of Cdk5. These results indicate that p35(nck5a) i s a physiological activator of Cdk5 in immature neurons and further su est that Cdk5 has another function in mature neurons.