SYNTHESIS AND REACTION OF NOVEL TRICYCLIC DYNEMICIN-A MODELS WITH METHYL-GROUP

New dynemicin A mimics with methyl group 2a and 2b were synthesized, a nd acid-induced hydrolyzed to see an electronic effect of substituent for epoxide opening. The model 2a with methyl group at C3 position was more rapidly transformed to diol 16a than 2b with methyl group at C2. This result suggests that any substituent at C3 position plays more i mportant role than any substituent at C2 position in the dynemicin A m imic activation.