RECENT ADVANCES IN THE MOLECULAR PHARMACOLOGY OF THE ALPHA(1)-ADRENERGIC RECEPTORS

This review is intended to discuss recent developments in the molecula r pharmacology of the alpha(1)-adrenergic receptor (alpha(1)-AR) subty pes. After a brief historical development, we will focus on the more c ontemporary issues having to do with this receptor family. Emphasis wi ll be put on recent data regarding the cloning, nomenclature, signalli ng mechanisms, and genomic organization of the alpha(1)-AR subtypes. W e will also highlight recent mutational studies that identify key amin o acid residues involved in ligand binding, as well as the role of the alpha(1)-AR subtypes in regulating physiologic processes.