Ak. Golenkov et al., EXTRATUMOR MECHANISMS OF OSTEOLYSIS IN MU LTIPLE-MYELOMA AND METHOD OF THEIR CORRECTION, Terapevticeskij arhiv, 68(7), 1996, pp. 58-61
In 70 patients with stage III multiple myeloma (MM) the authors studie
d spontaneous and lipopolysaccharide-induced production of interleukin
-1 (IL-1) and interleukin-6 (IL-6) by blood and bone marrow mononuclea
r cells, concentration of parathyroid hormone and vitamin D3 in the se
rum. Bone marrow density was measured at photon absorption (Gambro), i
n patients treated with osteoprotectors bonefos and oxidevit before an
d after therapy (3.5-6 month course). It is shown that in MM there is
a pathogenetic association between production of osteotropic IL-1, IL-
6 and bone demineralization. The cases with reduced concentration of C
a and P ions in the serum (4 and 5.7% of patients, respectively) and i
ncreased PTH concentration (7%) suggest the existence of new, extratum
or mechanisms of osteolysis. It is found that biphosphonates are optim
al osteoprotectors. Bonefos (chlodronat, Lieras, Finland) arrests oste
olysis proved by a significant increase of bone marrow density and cli
nical effect.