MONITORING OF PROTEIN-VOLEMIC PARAMETERS BY PLASMAPHERESIS IN PATIENTS WITH PARAPROTEINEMIC HEMOBLASTOSIS

We studied quantitative characteristics of plasma protein before, duri ng and after 133 plasmapheresis (PA) procedures in patients with multi ple myeloma and Waldenstrom's macroglobulinemia. A value of removed pl asma volume (RPV) was calculated as a part plasma volume (PV) before P A with consideration of quantity and consequence of replacement soluti on. In the case when we removed 30% of calculated PV we replaced it on ly with electrolyte solutions. In the case of 50% PV removing, the rep lacement was a combination of low molecular weight dextran and electro lyte solutions (1:2) or 5% albumin and electrolyte solutions. The resu lts support correlation between a level of total protein and RPV, kind of replacement solutions. We recommend two regression equations for e fficient and safety planning RPV and for prediction of protein level a fter PA. This simple and fast method can be used for prognosis of crit ic PA parameters, to decrease a risk of side effects and for optimal u se of albumin replacement solutions.