GAMMA-HYDROXYBUTYRIC ACID DECREASES THALAMIC SENSORY EXCITATORY POSTSYNAPTIC POTENTIALS BY AN ACTION ON PRESYNAPTIC GABA(B) RECEPTORS

Authors
EMRI Z ANTAL K CRUNELLI V
Citation
Z. Emri et al., GAMMA-HYDROXYBUTYRIC ACID DECREASES THALAMIC SENSORY EXCITATORY POSTSYNAPTIC POTENTIALS BY AN ACTION ON PRESYNAPTIC GABA(B) RECEPTORS, Neuroscience letters, 216(2), 1996, pp. 121-124
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
216
Issue
2
Year of publication
1996
Pages
121 - 124
Database
ISI
SICI code
0304-3940(1996)216:2<121:GADTSE>2.0.ZU;2-3
Abstract
The effect of gamma-hydroxybutyric acid (GHB) on the excitatory postsy naptic potential (EPSP) evoked in thalamocortical neurones of the rat dorsal lateral geniculate nucleus and ventrobasal thalamus was investi gated in vitro. GHB (0.1-5 mM) dose-dependently and reversibly decreas ed (36-78%) the amplitude of the sensory EPSP. This effect of GHB was blocked by the GABA(B) receptor antagonist CGP 35348 (1 mM). NCS 382 ( 1-3 mM), a putative GHB receptor antagonist, did not antagonise but we akly potentiated both the GHB-and baclofen-mediated decrease of the EP SP amplitude.