CONFLICT SITUATION INCREASES SEROTONIN RELEASE IN RAT DORSAL HIPPOCAMPUS - IN-VIVO STUDY WITH MICRODIALYSIS AND VOGEL TEST

Authors
MATSUO M KATAOKA Y MATAKI S KATO Y OI K
Citation
M. Matsuo et al., CONFLICT SITUATION INCREASES SEROTONIN RELEASE IN RAT DORSAL HIPPOCAMPUS - IN-VIVO STUDY WITH MICRODIALYSIS AND VOGEL TEST, Neuroscience letters, 215(3), 1996, pp. 197-200
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
215
Issue
3
Year of publication
1996
Pages
197 - 200
Database
ISI
SICI code
0304-3940(1996)215:3<197:CSISRI>2.0.ZU;2-O
Abstract
The release of serotonin (5-hydroxytryptamine, 5-HT) in the dorsal hip pocampus was measured using an in vivo microdialysis method in rats su bjected to the Vogel type conflict test. The conflict situation signif icantly increased 5-HT release in the dorsal hippocampus. Midazolam (0 .75 and 1.5 mg/kg i.p.) suppressed the dosage-dependently this increas ed 5-HT release, an inhibition closely associated with the attenuation of conflict behavior. These findings suggest that the activation of s erotonergic neuronal activity in the dorsal hippocampus is linked to m ediation of anxiety-related behavior.