CHRONIC INFLAMMATORY DEMYELINATING POLYNE UROPATHIES

A chronic Inflammatory demyelinating polyneuropathy (CIDP) is describe d both on the basis of authors' own observations and literary data. Th e disease is characterised by delayed onset with progredient, progredi ent-remittent and stable course of flaccid paresis of extremity togeth er with mild distal sensitive disturbances, albumino-cytologic dissoci ation and dysimmunoglobullnemia. Cranial nerves damages and vestibulo- cerebellar disturbances were observed in a number of patients. This co nfirms the Involvement of CNS in CIDP. The common character of clinica l, Immunological, laboratory and electrophysiological findings permits to consider CIDP and Guillain-Barre syndrome as autoimmune diseases. Meanwhile some recent findings on the formation of antibodies to perip heral nerves structures as well as high titers of antisulfamide and an tigangllosides antibodies permit to suggest CIDP as separate nosologic al unit. Additional clinical data and the evaluation of the role of et iological and pathogenetic mechanisms are necessary for the final conc lusion.