THE INFLUENCE OF SMALL DOSES OF NACOME ON THE EXCRETION OF HORMONES OF HYPOTHALAMO-HYPOPHYSEAL-ADRENAL SYSTEM IN PATIENTS WITH INFANTILE CEREBRAL PARALYSIS

The levels of hormones of hypothalamo-hypophyseal-adrenal system were measured in 14 10-14 year old children with infantile cerebral paralys is (ICP) with central catecholaminergic motor insufficiency. Contents of adrenocorticotropic hormone (ACTH), hydrocortisone (HC), somatotrop ic hormone, prolactin (P) were examined before and during Nacome admin istration (62,5 mg once daily in the morning). 110 patients of the sam e age with ICP and 18 children with aquired encephalopathy (EP) formed the control group. The elevations of ACTH, HC and P were revealed in spastic forms of ICP. Meanwhile nearly normal hormonal levels were obs erved in hyperkinetic forms of ICP and EP. The more pronounced effect was noted in ''dopamine-dependent'' children in which the drug's admin istration resulted in normalization of clinical and biochemical indice s. Hyperkinetic phenomena revealed the connection between the characte r of neuromotor dyskinesias and the state of hypothalamo-hypophyseal-a drenal axis which is regulated by dopamine. The data obtained show hyp ofunction of dopaminergic neurotransmitter cerebral systems in patient s with ICP that plays Important pathogenetic role In development of di sease with systemic manifestations.