ANTIBODIES TO BRAIN-TISSUE ANTIGENS IN EP ILEPTIC PATIENTS

The observation of 38 patients with different forms of epilepsy was ca rried out in terms of autoantibodies (aAB) to nervous tissue proteins: p18, p30 and S-100. The pathological Increase or decrease of aAB tite rs to at least one of the antigens (AG) mentioned above was found In 3 1 cases. The qualitatively new approach was further used for the revel ation of aAB to S-100. Not the very protein was adsorbed on the plates for Immuno-enzyme assay but antiidiotypic Abs which were the ''mirror reflection'' of corresponding protein molecules' determinants. The au thors suggested that the method permitted to estimate the level of aAB to the whole complex of AG determinants. Thus, the percent of positiv e tests was approximately twice higher. The index of aAB binding by co rresponding antiidiotypes was decreased In 29 patients. It's quite pos sible that It formed some conditions for brain tissue damages by aAB.