STERYL CELLOSOLVES REGULATE CHOLESTEROL-M ETABOLISM IN ISOLATED RABBIT HEPATOCYTES

Authors
MALYUGIN AV SHTEINSHNEIDER AY KOSYKH VA ALQUIER C LAFONT H MISHARIN AY
Citation
Av. Malyugin et al., STERYL CELLOSOLVES REGULATE CHOLESTEROL-M ETABOLISM IN ISOLATED RABBIT HEPATOCYTES, Bioorganiceskaa himia, 22(8), 1996, pp. 606-610
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
22
Issue
8
Year of publication
1996
Pages
606 - 610
Database
ISI
SICI code
0132-3423(1996)22:8<606:SCRCEI>2.0.ZU;2-C
Abstract
Synthesis of 3 beta-(2-hydroxyethoxy)cholest-5-ene, 3 beta-(2-hydroxye thoxy)cholest-5-en-7-one, 3 beta-(2-hydroxyethoxy)-7 beta-hydroxychole st-5-ene, 3 beta-(2-hydroxyethoxy)-5 alpha,6 alpha-epoxycholestane, an d 3 beta-(2-hydroxyethoxy)-5 alpha,6 beta-dihydroxycholestane was desc ribed. Substances obtained inhibited cholesterol biosynthesis in the r abbit hepatocyte cell culture with ID50 from 5.5(+/-0.7) x 10(-8) to 1 .3(+/-0.2) x 10(-5) M and also to a remarkable extent the cell protein biosynthesis.