RESISTANCE TO ACTIVATED PROTEIN-C (APC) IN INDIAN PATIENTS OF THROMBOPHILIA

Authors
PATI HP SRIVASTAVA A DAYAL S
Citation
Hp. Pati et al., RESISTANCE TO ACTIVATED PROTEIN-C (APC) IN INDIAN PATIENTS OF THROMBOPHILIA, INDIAN JOURNAL OF MEDICAL RESEARCH, 104, 1996, pp. 213-215
Citations number
15
Categorie Soggetti
Medicine, General & Internal",Immunology
Journal title
INDIAN JOURNAL OF MEDICAL RESEARCH → ACNP
ISSN journal
09715916
Volume
104
Year of publication
1996
Pages
213 - 215
Database
ISI
SICI code
0971-5916(1996)104:<213:RTAP(I>2.0.ZU;2-X
Abstract
In a pilot study, 28 consecutive patients with thrombosis and 23 age a nd sex matched healthy normal controls were investigated with normalis ed APC sensitivity ratio (n-APC-SR) to know the defect exists and if s o its prevalence in India. Six of the 28 (21.4%) thrombotic patients h ad n-APC-SR of < 0.76 (range 0.55 to 0.74) as compared to the normal c ontrol value (0.97+/-0.105). Our study shows APC resistance defect in a significant proportion (21.4%) of Indian patients with thrombotic di sorders.