DEVELOPMENT AND VALIDATION OF A REVERSED-PHASE LIQUID-CHROMATOGRAPHICMETHOD FOR ANALYSIS OF ASPIRIN AND WARFARIN IN A COMBINATION TABLET FORMULATION

Authors
MONTGOMERY ER TAYLOR S SEGRETARIO J ENGLER E SEBASTIAN D
Citation
Er. Montgomery et al., DEVELOPMENT AND VALIDATION OF A REVERSED-PHASE LIQUID-CHROMATOGRAPHICMETHOD FOR ANALYSIS OF ASPIRIN AND WARFARIN IN A COMBINATION TABLET FORMULATION, Journal of pharmaceutical and biomedical analysis, 15(1), 1996, pp. 73-82
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
15
Issue
1
Year of publication
1996
Pages
73 - 82
Database
ISI
SICI code
0731-7085(1996)15:1<73:DAVOAR>2.0.ZU;2-O
Abstract
A stability-indicating liquid chromatographic method for the simultane ous analysis of aspirin and warfarin in warfarin sodium/aspirin combin ation (DuP 647) tablets has been developed and validated. This paper p resents linearity, accuracy, precision, robustness, recovery, limits o f detection and quantitation, and cross-validation data. The method ha s been shown to be specific and stability-indicating, and to give resu lts comparable to existing methods for the individual components. Solu tion stability has been optimized for routine analysis.