Immunosuppression can allow organisms which are not usually pathogenet
ic to cause disease. Invasive fungal disease is becoming increasingly
prevalent because of the growing numbers of patients who are immunosup
pressed. Aspergillus species frequently form large masses of fungal el
ements, thrombin, and fibrin, within the vasculature. These masses can
then embolize, leading to organ infarction. Reported herein is a case
of aspergillosis invading the myocardium and causing widespread necro
sis and infarction. Although the epicardial coronary arteries were fre
e of disease, the patient ultimately died in cardiogenic shock.