PROINSECTICIDES OF OMEGA-FLUORINATED FATTY-ACIDS .1. METABOLISM OF FLUORINATED ENOL ESTERS IN LOCUST ORGANS OR HEMOLYMPH STUDIED BY F-19 NMR

F-19 NMR is used for monitoring the behavior of a fluorinated enol est er designed as proinsecticide of omega-fluorooctanoic add, in locust h emolymph or organ samples. The analysis performed directly in the biol ogical media avoids the problematic extraction of polar metabolites an d contributes to easier and faster monitoring. Thus a rapid demasking of omega-fluorooctanoic acid was evidenced during in vitro assays in h emolymph or fat body. For ex vivo assays the method clarifies a faster activation followed or accompanied by further metabolizations of the omega-fluorinated octanoic acid.