NEUROBORRELIOSIS - CLINICAL-FEATURES AND DIAGNOSIS IN AN ATYPICAL CASE

Borrelia burgdorferi can cause such a wide variety of symptoms that th e diagnosis is often difficult. Neurologic manifestations are often in augural in Lyme's disease, A case of severe meningoencephalitis in a 6 8-year-old man with an unremarkable medical history is reported, Stand ard diagnostic investigations were normal except for cerebrospinal flu id (CSF) analysis that showed marked lymphocytosis with increased leve ls of interferon alpha, Studies of late CSF and serum samples demonstr ated significant intrathecal production of antibodies to B. burgdorfer i and presence of genetic material from B. burgdorferi detectable by p olymerase chain reaction.