PARTIAL LIPODYSTROPHY ASSOCIATED WITH JUVENILE DERMATOMYOSITIS - REPORT OF 2 CASES

A 27-year-old woman and a 13-year-old girl diagnosed with juvenile der matomyositis in childhood developed clinical findings of partial lipod ystrophy 10 years after diagnosis. Exhaustive clinical and laboratory examinations showed an association with other abnormalities: hypertric hosis, steatohepatitis, and an abnormal insulin response to the glucos e loading test in the first patient. Hypertrichosis, steatohepatitis, insulin-resistant diabetes mellitus, and acanthosis nigricans were obs erved in the second patient. Renal function was normal in both patient s. Although a localized form of lipodystrophy has been reported associ ated with connective tissue disease (connective tissue lipoatrophy), t he partial form has been infrequently described in association with ju venile dermatomyositis.