SCREENING AND ANALYSIS OF POLAR PESTICIDES IN ENVIRONMENTAL MONITORING PROGRAMS BY COUPLED-COLUMN LIQUID-CHROMATOGRAPHY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
Ea. Hogendoorn et al., SCREENING AND ANALYSIS OF POLAR PESTICIDES IN ENVIRONMENTAL MONITORING PROGRAMS BY COUPLED-COLUMN LIQUID-CHROMATOGRAPHY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY, Journal of chromatography, 754(1-2), 1996, pp. 49-60
Citations number
37
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Screening and analysis of polar pesticides based on coupled-column rev
ersed-phase liquid chromatography (LC-LC) and GC- or LC-MS is a powerf
ul tool in the execution of environmental monitoring programmes. This
paper presents a unified approach utilising LC-LC screening followed b
y GC-MS confirmation. As polar pesticides are not generally amenable t
o GC a widely applicable derivation technique is used. The results dem
onstrate that the proposed LC and MS techniques are capable of analysi
ng a wide range of polar pesticides down to levels of 0.1 mu g/l (EU l
imit for drinking water). LC switching techniques for group analysis o
r individual compounds rely on the reversed-phase retention and the UV
detectability of the pesticides in combination with the choice of the
LC columns. Fast miniaturised derivatization prior to GC-MS forms an
integral part in the proposed strategy. In order to avoid extraction l
osses, derivation in the aqueous sample, preferably with electrophoric
reagents with enhanced sensitivity in GC-NICI-MS are employed where p
ossible. In this communication, method development and validation fitt
ing in the strategy are evaluated and the results of the combined appr
oach are discussed.