Jj. Bax et al., COMPARISON OF MYOCARDIAL UPTAKE OF FLUORINE-18-FLUORODEOXYGLUCOSE IMAGED WITH PET AND SPECT IN DYSSYNERGIC MYOCARDIUM, The Journal of nuclear medicine, 37(10), 1996, pp. 1631-1636
PET with F-18-fluorodeoxyglucose (FDG) can detect viable myocardium an
d predict functional recovery after revascularization. The use of PET
for clinical routine, however, is limited. Recently, imaging FDG with
SPECT was proposed. The aim of this study was to compare the diagnosti
c value of FDG-PET and FDG-SPECT in the detection of viable myocardium
in segments with abnormal wall motion, Methods: Twenty patients with
previous myocardial infarction were studied. All underwent FDG-PET and
FDG-SPECT during hyperinsulinemic glucose clamping. Regional perfusio
n was assessed with N-13-ammonia PET and early resting Tl-201- SPECT.
Regional wall motion was assessed with two-dimensional echocardiograph
y, The agreement between FDG/N-13-ammonia PET and FDG/Tl-201 SPECT to
detect viability in dyssynergic myocardium was 76%. On a patient basis
, PET and SPECT yielded comparable results in 17 of 20 patients. In a
subgroup of patients with LVEF less than or equal to 35% (n = 12), all
PET and SPECT viability data were identical. Conclusion: This study s
hows a good correlation between the detection of viability in dyssyner
gic myocardium with FDG/N-13-ammonia PET and FDG/Tl-201 SPECT, both On
a Segmental and patient basis.