INTERNAL AUTOCRINE REGULATION BY ERYTHROPOIETIN OF ERYTHROLEUKEMIC CELL-PROLIFERATION

Authors
STAGEMARROQUIN B PECH N GOLDWASSER E
Citation
B. Stagemarroquin et al., INTERNAL AUTOCRINE REGULATION BY ERYTHROPOIETIN OF ERYTHROLEUKEMIC CELL-PROLIFERATION, Experimental hematology, 24(11), 1996, pp. 1322-1326
Citations number
12
Categorie Soggetti
Medicine, Research & Experimental",Hematology
Journal title
Experimental hematology → ACNP
ISSN journal
0301472X
Volume
24
Issue
11
Year of publication
1996
Pages
1322 - 1326
Database
ISI
SICI code
0301-472X(1996)24:11<1322:IARBEO>2.0.ZU;2-C
Abstract
Antisense oligomers (18 mers) corresponding to the erythropoietin and erythropoietin receptor 5' coding sequences cause marked suppression o f proliferation of several lines of erythroleukemic cells. In these sy stems, phosphorothioate protected sense oligomers are inhibitory, whil e the unmodified sense oligomers have no significant-effect on cell gr owth. These data indicate that proliferation of some erythroleukemic c ells is under internal autocrine regulation by erythropoietin and its receptor.