BREAST AND PROSTATE-CANCER IN THE RELATIVES OF MEN WITH PROSTATE-CANCER

Objective To assess the risk of breast, ovarian and prostate cancer in the families of men with prostate cancer. Patients and methods A case -control study was performed by interviewing patients with prostate ca ncer and obtaining detailed information on family histories of cancer. Controls were hospital-based patients, of a similar age to the cases, with bladder cancer or benign prostatic hypertrophy. Results A total of 209 cases and 322, controls were interviewed; of the cases, 22.5% h ad family members with a history of one or more of breast, ovarian or prostate cancers, compared with 15.2% of controls (P<0.05). The odds r atio (OR) of having prostate cancer when there was a positive family h istory was 8.22 and the OR of a female relative of a patient with pros tate cancer having breast cancer was 1.51. There was no apparent incre ased risk of ovarian or any other cancer. Conclusions We confirm previ ous reports of an increased incidence of prostate cancer in the famili es of men with prostate cancer and report a similarly increased incide nce of breast cancer in female relatives. We suggest that detailed fam ily histories be taken routinely and intend to analyse blood samples p rovided from this study for genetic abnormalities.