ENDOGENOUS MTV-ENCODED SUPERANTIGENS ARE NOT REQUIRED FOR DEVELOPMENTOF MURINE AIDS

Authors
MCCARTY TC CHATTOPADHYAY SK SCHERER MT FREDRICKSON TN HARTLEY JW MORSE HC
Citation
Tc. Mccarty et al., ENDOGENOUS MTV-ENCODED SUPERANTIGENS ARE NOT REQUIRED FOR DEVELOPMENTOF MURINE AIDS, Journal of virology, 70(11), 1996, pp. 8148-8150
Citations number
32
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
70
Issue
11
Year of publication
1996
Pages
8148 - 8150
Database
ISI
SICI code
0022-538X(1996)70:11<8148:EMSANR>2.0.ZU;2-K
Abstract
Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tu mor virus (MTV) might he the source of stimulation was studied by usin g Mtv mice, Mtv(-) mice developed typical MAIDS, excluding a requireme nt for Mtv-encodcd SAGs in the pathogenesis of this disorder.