MURINE LEUKEMIA VIRUS-BASED TAT-INDUCIBLE LONG TERMINAL REPEAT REPLACEMENT VECTORS - A NEW SYSTEM FOR ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS GENE-THERAPY

Authors
CANNON PM KIM N KINGSMAN SM KINGSMAN AJ
Citation
Pm. Cannon et al., MURINE LEUKEMIA VIRUS-BASED TAT-INDUCIBLE LONG TERMINAL REPEAT REPLACEMENT VECTORS - A NEW SYSTEM FOR ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS GENE-THERAPY, Journal of virology, 70(11), 1996, pp. 8234-8240
Citations number
56
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
70
Issue
11
Year of publication
1996
Pages
8234 - 8240
Database
ISI
SICI code
0022-538X(1996)70:11<8234:MLVTLT>2.0.ZU;2-V
Abstract
We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type I U3 and R sequences in place of the MLV U3 and R re gions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of Tat. TIN vectors have several advantages for anti-HIV gene therapy applications.