POSSIBLE ROLE OF THE V3 DOMAIN OF GP120 IN RESISTANCE TO AN AMPHOTERICIN-B DERIVATIVE (MS8209) BLOCKING HUMAN-IMMUNODEFICIENCY-VIRUS ENTRY

Authors
PLESKOFF O SOL N MARRAKCHI H SERLIN M SEMAN M ALIZON M
Citation
O. Pleskoff et al., POSSIBLE ROLE OF THE V3 DOMAIN OF GP120 IN RESISTANCE TO AN AMPHOTERICIN-B DERIVATIVE (MS8209) BLOCKING HUMAN-IMMUNODEFICIENCY-VIRUS ENTRY, Journal of virology, 70(11), 1996, pp. 8247-8251
Citations number
39
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
70
Issue
11
Year of publication
1996
Pages
8247 - 8251
Database
ISI
SICI code
0022-538X(1996)70:11<8247:PROTVD>2.0.ZU;2-C
Abstract
MS8209, an amphotericin B derivative blocking human immunodeficiency v irus type 1 (HIV-1) entry after CD4 binding, neutralized the HIV-2 str ains EHO and ROD(10) but not ROD(CEM). In the V3 domain of gp120, ROD( CEM) differed from ROD(10) at two positions (a threonine instead of an isoleucine at position 312 and an arginine instead of a glutamine at position 329), and drug resistance was conferred to HIV-1 by substitut ion of the ROD(CEM) V3 but not the ROD(10) V3. V3 mutations may preven t the interaction of gp120 with MS8209 or modify the mechanism of viru s entry, rendering it less accessible to neutralization.