CLINICAL NEUROPHYSIOLOGICAL CORRELATIONS IN MIGRAINE

The more accurate definition of the role of cerebral mechanism in migr aine development by means of contingent negative deviation (CND) metho d was the aim of this investigation. The significant alterations of so me parameters were revealed In patients with migraine between the fits as compared with controls. The same indices were normal during the ve ry fits. The CND Indices were similar in patients with chronic Headach e of strain and healthy individuals. The clinical neurophysiological a nalysis didn't reveal any significant dependence of CND changes clinic al pecullarities and anxious and depressive disorders. The significant elevation of CND parameters observed between the attacks suggests pre sense of superfluous activity in cerebral structures (noradrenergic ma inly) in patients with migraine without aura. Such alterations in thei r action lead, apparently, to headache attack development.