CHANGES IN CHOLINESTERASE ACTIVITIES AFTER DAUNORUBICIN ADMINISTRATION TO RABBITS

1 Acetyl- and butyrylcholinesterase (AChE, BuChE) activities were stud ied in rabbits with experimentally induced daunorubicin cardiomyopathy . 2 A significant decrease of the plasma BuChE in the daunorubicin gro up was observed. 3 In the daunorubicin group, AChE activity in the hea rt was significantly decreased only in the interventricular septum. 4 BuChE activity was significantly decreased in the cardiac septum and v entricles and in the liver following daunorubicin treatment. 5 Changes in cholinesterase activities are probably caused by an effect of daun orubicin oon protein synthesis during the development of certain types of cardiomyopathy.