In animal experimentation, long-term studies have contributed substant
ially to our knowledge of genetics in particular, and of nutrition, ph
ysiology, and reproduction, to lesser extents. Long-term genetic selec
tion experiments have yielded information on selection limits, dissipa
tion of genetic variance over time, and created unique lines which may
be utilized as consumer demands shift. Costs of long-term experimenta
tion are not inordinately high in comparison to other experimentation,
if economic animal species are used and returns from animal products
are recovered to help finance the experiment. Government finance is, h
owever, required for long-term experimentation, as private industry ha
s little motivation for this work. The paper outlines recent significa
nt contributions of long-term experimentation, and provides guidelines
for planning experiments.