TIME-VARYING ACTIVATION OF DIFFERENT CYTOARCHITECTONIC AREAS OF THE HUMAN SI CORTEX AFTER TIBIAL NERVE-STIMULATION

We followed cortical activation in eight healthy adults after electric stimulation of the left tibial nerve at the ankle. The recordings wer e made noninvasively with a whole-scalp neuromagnetometer. The first c ortical activation peaked in different subjects at 37-45 ms in the foo t area of the right (contralateral) primary somatosensory (SI) cortex, with mean source current orientation perpendicular to the longitudina l fissure, The current orientation changed within the next 5 ms counte rclockwise in all subjects, with a mean rotation of 64 degrees. A two- dipole time-varying model, with two dipoles differing by 28-119 degree s in orientation but less than 1 cm in location in the right SI cortex , explained the signal pattern satisfactorily during the first 100 ms. We suggest that the observed field patterns reflect sequential activa tion of different cytoarchitectonic areas in the foot SI cortex and im ply considerable differences in the structural organization between th e foot and the hand SI cortices. The initial activation is considered to take place in area 3b facing the interhemispheric fissure, and the later source, due to the systematic rotations of the field patterns, i s assumed to reflect activation of area 5 in the anterior wall of the marginal ramus of the cingulate sulcus. (C) 1996 Academic Press, Inc.