ELIMINATION OF IOMEPROL BY HEMODIALYSIS

lomeproI is commercially a relatively new type of contrast medium. The re have been no reports concerning its dialysability and safety when a dministered to patients with end-stage renal failure undergoing regula r therapeutic hemodialysis (HD). One hundred milliliters of iomeprol ( 350 mgl/ml) was injected intravenously at computed tomography in 10 pa tients suffering from chronic renal failure. HD was then performed wit hin 30 min after the start of iomeprol injection. The duration of HD w as 4 h and brood samples were taken at 15, 30 min, 1, 2 and 4 h after its start. Mean dialysance of urea was 176.0-182.9 ml/min, compared to 131.4-133.3 ml/min for iomeprol. Elimination rate of iomeprol was 821 .4 +/- 4.6% 4 h after the start of HD. Two of the 10 patients had side effects. One of them complained of a heat sensation and the other of sneezing and rash. As 4-h HD effectively removed iomeprol from the bod y and there were no severe side effects, it is concluded that iomeprol is suitable for HD patients.