Objective: To describe postoperative CT and MRI findings and their tim
e course in uncomplicated cases after stereotactic volumetric resectio
ns of brain lesions. Materials and methods: One-hundred twenty-eight i
maging studies (CT, 86; MRI, 42), performed 6 to 2 years after 52 ster
eotactic operations, were retrospectively reviewed and analyzed in rel
ation to time of surgery in cases without complications. Results: The
extent of resection bed did not change during the first week after ope
ration; reduction of size then began and continued up to 3-6 months. M
ass effect and edema showed no change during the first 4 days, then la
ter regressed gradually. Pneumocephalus was found in 58% of cases in t
he first 3 weeks, but never later. Benign, surgically-induced enhancem
ent appeared at the margins of encephalotomy and retractor trajectory
at the end of the first postoperative week, became more prominent duri
ng the following weeks, and lasted up to 3-5 months. In the majority o
f cases enhancement prevented recognition of the residual tumor. Dural
enhancement was observed at the craniotomy site very early after the
operation and persisted up to 1 year. Meningeal enhancement over conve
xities was found in 44% of MRI studies. Conclusion: Extent of the rese
ction bed, mass effect, edema, and pneumocephalus show, in uncomplicat
ed cases, a regular regression during the postoperative period. The ti
me course of enhancement is complex and can be a source of diagnostic
misinterpretation.