SYNTHESIS AND CHARACTERIZATION OF A NEW ISOCYANATO CARBORANE ANION [7-0=C=N-7-CB10H12](-) - STUDY ON ITS REACTIVITY TOWARD AMINO CONTAININGCOMPOUNDS

The new isocyanato carborane anion, [7-O=C=N-7-CB10H12](-) was prepare d by the reaction of 7-H3N-7-CB10H12 with triphosgene in the presence of triethylamine. The structure of this compound was established by H- 1, B-11 and C-13 NMR as well as IR spectroscopy. The reactivity of thi s compound with a series of organic amines was investigated. The resul ting ureas were obtained in good to excellent yields. This approach is suitable for development of compounds for use in tumor selective Boro n Neutron Capture Therapy (BNCT). Copyright (C) 1996 Elsevier Science Ltd