RENAL-VEIN THROMBOSIS AND CONSTITUTIONAL PROTEIN-S DEFICIENCY

Venous and arterial thrombosis due to a constitutional protein S defic iency is well-known. We report the case of a 36 year-old patient admit ted to hospital in 1991 for primary renal vein thrombosis due to a con stitutional protein S deficiency of type I. The diagnosis was made by CT scan and angiography. Left nephrectomy, which was made because of d oubt with regard to subjacent neoplasm, showed left renal vein thrombo sis and multiple renal infarcts. In 1994, after 4 months of discontinu ation of oral anticoagulants, the patients presented pulmonary embolis m documented by pulmonary scintigraphy and CT scan, partial portal thr ombosis and sural thrombophlebitis documented by echography coupled wi th Doppler. To our knowledge, this is the first reported case of a con stitutional protein S deficiency associated with primary renal vein th rombosis.