A RANDOMIZED COMPARATIVE-STUDY OF HIGHLY PURIFIED FOLLICLE-STIMULATING-HORMONE AND HUMAN MENOPAUSAL GONADOTROPIN FOR OVARIAN HYPERSTIMULATION IN AN OOCYTE DONATION PROGRAM

A randomized comparative study of highly purified human follicle-stimu lating hormone (FSH-NP), administered s.c., and human menopausal gonad otrophin (HMG), administered i.m., was carried out in 41 volunteer ooc yte donors, The response to ovarian hyperstimulation was similar ill b oth groups. One cycle in both groups was cancelled, The number of oocy tes recovered was 16.0 +/- 7.9 (mean +/- SD) following stimulation wit h 32.8 +/- 10.3 ampoules of FSH-HP (It = 19) over 12.3 +/- 1.7 days, F ollowing stimulation with 29.8 +/- 10.6 ampoules of HMG over 11.5 +/- 1.6 days, the number of oocytes collected was 18.4 +/- 12.7 (n = 20), The oocyte recipients were allocated 9.2 +/- 3.6 oocytes in the FSH-HP group (ii = 33) and 9.6 +/- 4.6 oocytes in the HMG group (n = 37), Th e fertilization rate (2PN/cell) was significantly higher in the HMG gr oup (48%, 170/355) than in the FSH-HP group (36%, 109/304) (P < 0.01), The number of embryos transferred per recipient was 2.0 +/- 0.4 in th e FSH-HP and 2.0 +/- 0.3 in the HMG group. The pregnancy rate per embr yo transfer was 25% in the FSH-HP (5/20) and 26% (8/31) in the HMG gro up, Fertile donors with body mass index greater than or equal to 25 ma de up a poor responder group to s.c. FSH-HP, possibly indicating reduc ed absorption of the drug.