OLIGONUCLEOTIDE LABELING METHODS .4. DIRECT LABELING REAGENTS WITH A NOVEL, NON-NUCLEOSIDIC, CHIRALLY DEFINED 2-DEOXY-BETA-D-RIBOSYL BACKBONE

Novel solid supports and CE-phosphoramidite reagents have been prepare d featuring a unique 2'-deoxyribosyl backbone. These chirally pure rea gents form the basis of an oligonucleotide labeling system which provi des diastereomerically pure oligonucleotides.